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Preliminary cardiovascular outcome data on tirzepatide in type 2 diabetes The above-mentioned preliminary cardiovascular safety data from the SURPASS-4 study demonstrated no excess cardiovascular risk associated with tirzepatide therapy (54, 73)

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doi: 10.3390/ijms160920195

At this point in the disease course, even meaningful shifts in fluid biomarkers may not translate into measurable improvements in cognition or daily functioning over a two-year trial, Koychev stated