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Solun B., Marcoviciu D., and Dicker D., Dipeptidyl Peptidase4 Inhibitors and Their Effects on the Cardiovascular System, Current Cardiology Reports 15, no

This dominance is largely attributed to the widespread use of glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide (Wegovy) and tirzepatide (Zepbound), which have shown significant effectiveness in weight management

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GLP-1 receptor agonist therapy represents one of the most significant advances in medical weight loss and metabolic optimization, not because it's a quick fix, but because it works by addressing the underlying biological drivers of weight gain, appetite dysregulation, and cardiometabolic disease

Further research is however needed to elucidate the long-term impact of GLP-1RAs on skeletal muscle and to optimize interventions that preserve muscle mass while retaining metabolic benefits