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Semaglutide is generally well-tolerated, with the most common side effects being nausea and vomiting

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The Beneficial Side The thermogenic effect of glucagon activation is part of why retatrutide works so well

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The reduction in BMI for those receiving tirzepatide and other incretin-based therapies is substantial but is not instantaneous

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patients and clinicians should refer to the current NICE topic page for the up-to-date appraisal status of tirzepatide for weight management, as this may change over time

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Available at: [accessed March 2026]. The SELECT Trial: A Brief Summary

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