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Top-dose phentermine and topiramate was not cost-effective, with an ICER of $317,010 per QALY gained vs lifestyle counselling
More practical alternatives include bioelectrical impedance analysis scales, skinfold measurements, and simple circumference tracking
These drugs demand the right patient selection, dosing strategy, and clinical oversight
Long-term body composition changes also depend heavily on: nutrition, strength training, sleep quality, stress levels, hormone balance, activity levels, and consistency
