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Generally, products that are only used by adult current and former cigarette smokers trying to avoid combustible cigarettes, and not by young people or people who have never used nicotine products before, have the potential to improve the health of a population. Perhaps because of this historic move by the FDA, e-cigarettes have recently gained a lot of attention as an alternative to smoking traditional cigarettes

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Simply submitting an application does not give companies safe harbor from enforcement - if a product has not been authorized for sale by the FDA, it's on the market illegally

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Wakakura M, Mogi A, Ichibe Y, Okada K, Hasebe H