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Side effects are generally minimal, but some individuals may experience gastrointestinal discomfort

It is identified as one of the most important medications needed in a basic health system

Recent studies further support a link between NOX5, oxidative stress, endothelial dysfunction and systolic hypertension

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In addition, a major problem in the treatment of NDs is the limited delivery of many medicinal products to the brain due to the presence of the bloodbrain barrier (BBB), which makes it difficult to reach sufficient concentrations of active substances in the brain and decreases their bioavailability 13